Buy Tiletamine zolazepam online without prescription NMDA antagonist benzodiazepine tranquilizer
Tiletamine zolazepam is an NMDA antagonist benzodiazepine tranquilizer combination of equal amounts with the dose based upon the combined weight of both drugs. Tiletamine is more potent and has a longer duration of action compared to ketamine. Tiletamine zolazepam is used as an alternative to ketamine combinations (ketamine+opioid, benzodiazepine, or alpha2-agonist) to produce immobilization, sedation, or surgical anesthesia for minor to moderate procedures. Depending upon the dose and species, tiletamine zolazepam may be associated with prolonged recoveries. Ocular, laryngeal, pharyngeal, and pedal reflexes remain intact. Side effects associated with tiletamine zolazepam include a dose-dependent decrease in cardiac output and hypotension. Buy Tiletamine zolazepam online without prescription
In rabbits, tiletamine zolazepam has been associated with renal toxicity when used at surgical anesthetic doses (Brammer et al., 1991). Renal toxicity was linked to the tiletamine component. When used at lower doses in combination with xylazine, tiletamine zolazepam produced mean surgical anesthesia duration of 72 minutes versus 35 minutes for xylazine ketamine with no nephrotoxicity observed (Doerning et al., 1992). In guinea pigs, tiletamine zolazepam doses up to 50 mg/kg produced short-term immobilization, but inadequate surgical anesthesia (Radde et al., 1996). In hamsters, anesthesia but not analgesia was achieved at doses of 50–80 mg/kg (Silverman et al., 1983Tiletamine/Zolazepam
Tiletamine/zolazepam (Telazol™) has been used as an anesthetic for rats. A mixture of tiletamine and zolazepam, it is presented as a powder for reconstitution. Used alone, at doses of 20 to 40 mg/kg, Telazol™ produces 30 to 60 minutes of surgical anesthesia, but corneal, pedal and swallowing reflexes are retained, so the assessment of anesthetic depth is difficult. The addition of xylazine greatly improves the analgesia produced but results in marked cardiovascular depression, and the addition of butorphanol also increases analgesia but at the cost of variable respiratory depression (Ward et al., 1974; Silverman et al., 1983; Wilson et al., 1993). Given the cost of Telazol™, its relatively short shelf life following reconstitution, and questionable analgesia there seems little reason to use it in preference to the ketamine mixtures described above.